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This conclusion presents some closing thoughts on the key concepts discussed in the preceding chapters of this book. The book focuses on the analysis of plasmonic refractive index sensors. Design and numerical simulation of two sensor configurations based on a metal-insulator-metal waveguide that can be used both for refractive index measurements and as a plasmonic filter were discussed. Major benefits of these sensors include the compatibility with the existing fiber-optic data transmission networks, high resistance to the external chemical and radiation factors, the immunity to electromagnetic interference, high sensitivity to the design parameters, and easy integration into measurement systems. Fiber-optic sensors that rely on a frequency shift of transmitted radiation show essentially higher immunity to disturbances thanks to operating on a principal wavelength. The proposed solutions may show promise in situations where an optical signal is directly fed to the input of a specialized processor.