The immunogenicity of an HIV-1 Gag conserved element DNA vaccine in people with HIV and receiving antiretroviral therapy

20237 citationsJournal Articlegreen Open Access

Authors

Jeffrey M. Jacobson · Case Western Reserve University

Barbara K. Felber · National Cancer Institute

Huichao Chen · Harvard University

George N. Pavlakis · National Cancer Institute

James I. Mullins · University of Washington

Stephen C. De Rosa · Fred Hutch Cancer Center

Daniel R. Kuritzkes

Abstract

A DNA-delivered HIV-1 Gag conserved element vaccine boosted by a combination of this vaccine with a full-length p55 Gag DNA vaccine induced a new conserved element-directed cellular immune response in approximately half the treated PWH on ART.

Topics & Keywords

HIV Research and Treatment HIV/AIDS drug development and treatment HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: AIDS

Volume 38, Issue 7, pp. 963-973

DOI: 10.1097/qad.0000000000003804

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