Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8 + T cell-mediated antitumour immunity and improves anti-PD-1 efficacy

202366 citationsJournal Articlehybrid Open Access

Authors

Ning Cai · Tongji Hospital

Kun Cheng · Tongji Hospital

Yue Ma · Fudan University

Sha Liu · Tongji Hospital

Ran Tao · Tongji Hospital

Yani Li · Tongji Hospital

Danfeng Li · Tongji Hospital

Abstract

CTNNB1 GOF induces a suppressive TIME by activating secretion of MMP9. Targeting MMP9 reshapes TIME and potentiates anti-PD-1 efficacy in CTNNB1 GOF HCC.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses Galectins and Cancer Biology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 73, Issue 6, pp. 985-999

DOI: 10.1136/gutjnl-2023-331342

Field-Weighted Citation Impact: 15.17

Command Palette

Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8 <sup>+</sup> T cell-mediated antitumour immunity and improves anti-PD-1 efficacy

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details