Evaluation of the available animal models for Bartonella infections

The diseases caused by the <i>Bartonella</i> genus of bacteria are clinically diverse, and can be challenging to cure. The study of bartonellosis has been hampered by the lack of a suitable animal model. Preclinical studies for novel therapeutics and a competent host for vector transmission studies are needed to fill critical knowledge gaps. The studies included here are a representation of in vivo <i>Bartonella</i> research and the corresponding challenges. This review examines the current state of available animal models by assessing the success of various model species and strains in <i>Bartonella</i> infection. With a focus on the strengths and weaknesses of current animal models, the importance of these models for improvement of human health and veterinary care is emphasized.