Spindle cell rhabdomyosarcomas: With <i>TFCP2</i> rearrangements, and novel <i>EWSR1::ZBTB41</i> and <i>PLOD2::RBM6</i> gene fusions. A study of five cases and review of the literature

EWSR1/FUS::TFCP2-rearranged SS-RMS is a rare rhabdomyosarcoma subtype, affecting predominantly young adults with average age at presentation 34 years (median 29.5 years; age range 7-86 years), with a predilection for craniofacial bones, rapid clinical course with frequent bone and lung metastases, and poor prognosis (3-year overall survival rate 28%).