Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19

20237 citationsJournal Articlehybrid Open Access

Authors

Jasmin Sidhu · Imperial College London

Matthew K. Siggins · Imperial College London

Felicity Liew · Imperial College London

Clark D Russell · Centre for Inflammation Research

Ashley Sanchez Sevilla Uruchurtu · Imperial College London

Christopher Davis · University of Liverpool

Lance Turtle ·

Abstract

Defective early mucosal anti-viral responses anticipate fatal COVID-19 but are not associated with viral load. Early mucosal immune responses may define the trajectory of severe COVID-19.

Topics & Keywords

COVID-19 Clinical Research Studies SARS-CoV-2 and COVID-19 Research Long-Term Effects of COVID-19

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 230, Issue 1, pp. e17-e29

DOI: 10.1093/infdis/jiad590

Field-Weighted Citation Impact: 1.36