cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation

2024106 citationsJournal Articlegold Open Access

Authors

Jingwen Liu · Chengdu University of Traditional Chinese Medicine

Jing Zhou

Yuling Luan · Shanghai University of Traditional Chinese Medicine

Xiaoying Li · Shanghai University of Traditional Chinese Medicine

Xiangrui Meng

Wenhao Liao

Jianyuan Tang · Second Affiliated Hospital of Chengdu University of Traditional Chinese

Zheilei Wang · Second Affiliated Hospital of Chengdu University of Traditional Chinese

Abstract

This review aims to provide insight into the critical roles and regulatory mechanisms of the crosstalk network of cGAS-STING, inflammasomes and pyroptosis, and to highlight some promising directions for future research and intervention.

Topics & Keywords

interferon and immune responses Inflammasome and immune disorders Viral Infections and Vectors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cell Communication and Signaling

Volume 22, Issue 1, pp. 22-22

DOI: 10.1186/s12964-023-01466-w

Field-Weighted Citation Impact: 25.20