Accelerated immune ageing is associated with COVID-19 disease severity

202426 citationsJournal Articlegold Open Access

Authors

Janet M. Lord · Queen Elizabeth Hospital Birmingham

Tonny Veenith · NIHR Surgical Reconstruction and Microbiology Research Centre

Jack Sullivan · Queen Elizabeth Hospital Birmingham

Archana Sharma‐Oates · University of Birmingham

Alex Richter · University of Birmingham

Neil Greening · University of Leicester

Hamish McAuley

Abstract

Our analyses reveal a state of enhanced immune ageing in survivors of severe COVID-19 and suggest this could be related to SARS-Cov-2 infection. Our data support the rationale for trials of anti-immune ageing interventions for improving clinical outcomes in these patients with severe disease.

Topics & Keywords

COVID-19 Clinical Research Studies Long-Term Effects of COVID-19 Tryptophan and brain disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Immunity & Ageing

Volume 21, Issue 1, pp. 6-6

DOI: 10.1186/s12979-023-00406-z

Field-Weighted Citation Impact: 9.65