PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression

202423 citationsJournal Articlegold Open Access

Authors

Zi-Mei Peng · First Affiliated Hospital of Jiangxi Medical College

Xiaojian Han · Jiangxi Provincial People's Hospital

Tao Wang · First Affiliated Hospital of Jiangxi Medical College

Jianjun Li · Soochow University

Chunxi Yang · First Affiliated Hospital of Jiangxi Medical College

Fangfang Tou · First Affiliated Hospital of Jiangxi Medical College

Zhen Zhang

Abstract

Our study established the USP5-PFKP axis as an important regulatory mechanism of TNBC progression and provided a rationale for future therapeutic interventions in the treatment of TNBC.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Ubiquitin and proteasome pathways Mitochondrial Function and Pathology

Publication Details

Published in: Breast Cancer Research

Volume 26, Issue 1, pp. 10-10

DOI: 10.1186/s13058-024-01767-z

Field-Weighted Citation Impact: 6.68

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PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression

Authors

Abstract

Topics & Keywords

Publication Details