Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation

202413 citationsJournal Articlegold Open Access

Authors

Laura Godfrey · University of Duisburg-Essen

Jan Förster · German Cancer Research Center

Sven‐Thorsten Liffers · University Hospital Heidelberg

Christopher Schröder · University of Duisburg-Essen

Johannes Köster · University of Duisburg-Essen

Leonie Henschel · University of Bonn

Kerstin U. Ludwig

Abstract

Overall, the concept of acquired therapy resistance as a result of the expansion of a single cell clone with epigenetic plasticity sheds light on genetic, epigenetic and phenotypic patterns during evolvement of treatment resistance in a tumor with high adaptive capabilities and provides potential for reversion through epigenetic targeting.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Cancer Genomics and Diagnostics Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Epigenetics

Volume 16, Issue 1, pp. 13-13

DOI: 10.1186/s13148-024-01623-z

Field-Weighted Citation Impact: 3.70