Inclusion of deuterated glycopeptides provides increased sequence coverage in hydrogen/deuterium exchange mass spectrometry analysis of SARS‐CoV‐2 spike glycoprotein

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Authors

Christopher A. Haynes · Centers for Disease Control and Prevention

Theodore R. Keppel · Centers for Disease Control and Prevention

Betlehem Mekonnen · Centers for Disease Control and Prevention

Sarah H. Osman · Centers for Disease Control and Prevention

Yu Zhou · Centers for Disease Control and Prevention

Adrian R. Woolfitt · Centers for Disease Control and Prevention

Jakub Baudys

Abstract

Inclusion of deuterated glycopeptides improves the analysis of the conformational dynamics of glycoproteins such as viral surface antigens and cellular receptors.

Topics & Keywords

Influenza Virus Research Studies Mass Spectrometry Techniques and Applications Protein Structure and Dynamics

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Rapid Communications in Mass Spectrometry

Volume 38, Issue 5, pp. e9690-e9690

DOI: 10.1002/rcm.9690

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