IgE to cross‐reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins

Our results contribute to dissect the immunological origins, onset, evolution and risk factors of CCD-sIgE response in childhood, and raise the hypothesis that group 1 and/or 4 allergen molecules of grass pollen are major inducers of these antibodies through an antigen-specific, T-B cell cognate interaction.