Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia

20241 citationsJournal Articlegold Open Access

Authors

Sydney Fobare · The Ohio State University

Ola A. Elgamal · University of Cincinnati

Mark Wunderlich · Cincinnati Children's Hospital Medical Center

Emily Stahl · The Ohio State University

Abeera Mehmood · The Ohio State University

Casie Furby · University of Cincinnati

James R. Lerma

Abstract

Despite evidence that EZH2 silencing in MDS/MPN can promote AML pathogenesis, our data demonstrate that the therapeutic inhibition of EZH2 in established AML has the potential to improve survival.

Topics & Keywords

RNA Interference and Gene Delivery Retinoids in leukemia and cellular processes MicroRNA in disease regulation

Publication Details

Published in: Cancers

Volume 16, Issue 3, pp. 569-569

DOI: 10.3390/cancers16030569

Field-Weighted Citation Impact: 0.23

Command Palette

Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia

Authors

Abstract

Topics & Keywords

Publication Details