Voltammetric Determination of Metrafenone Using an Iridium Oxide Nanoparticle – Ionic Liquid Nanocomposite Modified Glassy Carbon Electrode

In this study, the first sensitive voltammetric nanosensor was developed for the determination of metrafenone. For this purpose, iridium oxide nanoparticles (IrOxNPs) were synthesized, and a nanocomposite was formed on the glassy carbon electrode with IrOxNPs and an ionic liquid (IL). The influence of pH on the metrafenone response was examined using phosphate and Britton-Robinson buffers as a function of pH. The influence of scan rate on the response to metrafenone was investigated in pH 7.0 phosphate buffer where the highest peak current was obtained and the peak shape was good. It was concluded that the oxidation occurred by the adsorption and diffusion mechanisms. According to cyclic voltammetry measurements for metrofenone, a single irreversible anodic peak was observed in all buffer solutions. Using the relationship between the peak potential and the logarithm of the scan rate, the electron number for the oxidation process was determined to be 2. Using adsorptive stripping differential pulse voltammetry, the detection limits for standard and the serum samples were 0.08 mg/L and 0.07 mg/L, respectively, and the calibration curve was linear up to 1.4 mg/L. The developed nanosensor was also employed to analyze to commercial preparations and good recovery values were obtained.