Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice

202425 citationsJournal Articlegold Open Access

Authors

Yixiao Xiong · West China Hospital of Sichuan University

Xin Liu · Sichuan University

Ling Jiang · West China Second University Hospital of Sichuan University

Tao Hao · Chengdu Fifth People's Hospital

Yanyan Wang · West China Hospital of Sichuan University

Tao Li · West China Hospital of Sichuan University

Abstract

The present study contributes to a deeper understanding of the specific mechanisms by which ferroptosis is involved in the development of HFpEF and suggests that inhibition of ferroptosis may mitigate the progression of HFpEF. In addition, eleven hub genes were recognized as potential drug binding targets.

Topics & Keywords

Ferroptosis and cancer prognosis Cancer-related molecular mechanisms research RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Translational Medicine

Volume 22, Issue 1, pp. 199-199

DOI: 10.1186/s12967-023-04734-y

Field-Weighted Citation Impact: 10.68