Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women

202429 citationsJournal Articlehybrid Open Access

Authors

Nina Mars · Broad Institute

Sini Kerminen · University of Helsinki

Max Tamlander · University of Helsinki

Matti Pirinen · University of Helsinki

Eveliina Jakkula · University of Helsinki

Kirsimari Aaltonen · University of Helsinki

Tuomo J Meretoja ·

Abstract

Using real-life screening data, this study demonstrates the effectiveness of a breast cancer PRS for risk stratification, alone and combined with FH and PVs. Further research is required to evaluate their impact in a prospective risk-stratified screening program, including cost-effectiveness.

Topics & Keywords

BRCA gene mutations in cancer Genetic Associations and Epidemiology Nutrition, Genetics, and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 42, Issue 13, pp. 1477-1487

DOI: 10.1200/jco.23.00295

Field-Weighted Citation Impact: 16.04