Survival of patients with hepatocellular carcinoma treated with immunotherapy experience of a third level center.

Hepatocellular carcinoma (HCC) ranks sixth among tumors, the third cause of death worldwide and accounts for 85-90% of primary liver tumors. Recently, the use of immunotherapy as first-line treatment offers a survival of 18 months. The objective of this study is to assess the survival and adverse effects of the different immune checkpoint inhibitor therapies in our population Patients who received immunotherapy at the Central Military Hospital from January 2021 to April 2023 were included. The following were recorded: leukocytes, hemoglobin, platelets, PT, INR, BT, AST, ALT, ALP, albumin, MELD, MELD-Na, ALBI, MELD 3.0 before and after treatment, calculation of survival, progression-free time and adverse effects 18 patients with stage A were included 2 patients, BCLC B 6 patients and BCLC C 10 patients, age 67.72 ± 14.40 years, 11 (61%) men, the following immunotherapy schemes were given: atezolizumab + bevacizumab 13 patients and 5 patients with Nivolumab. The following variables were compared before and after immunotherapy: leukocytes, hemoglobin, platelets, PT, INR, BT, AST, ALT, ALP, albumin, MELD, MELD-Na, ALBI, MELD 3.0. Without finding statistical differences (Table 1). Adverse effects were 1 patient presented with clostridiode and 2 with immune-mediated hepatitis without improvement after treatment, which required suspension of immunotherapy and initiation of second line treatment. Overall survival was 19 months and progression-free time 15 months. The overall survival of the patients was 19 months, the adverse effects that the patients appeared were similar to those reported in the literature.