P532: Development, implementation, and preliminary results of rapid targeted genomic analysis in the newborn period

Children’s Hospital of Philadelphia (CHOP) is committed to improving diagnostics and therapeutics for children by leveraging genomic data. One project, “Baby Eagle”, utilizes the CHOP-developed rapid Targeted Analysis of the Genome for Infants (rTAG-I) test, a rapid genomic test for infants in the neonatal intensive care units (NICU) to allow for early diagnosis, implementation of targeted management, recurrence risk counseling and reduced overall costs. A quality improvement framework was utilized to develop Baby Eagle’s primary aim: To decrease the time from genetic consult to disclosure of preliminary actionable genomic sequencing results to under 7 days, while expanding the cohort of NICU patients eligible for rapid genomic sequencing, regardless of race and ethnicity, by December 2023.