Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis

202478 citationsJournal Articlehybrid Open Access

Authors

Anne H. Cross · Washington University in St. Louis

Jeffrey M. Gelfand · University of California, San Francisco

Simon Thebault · University of Pennsylvania

Jeffrey L. Bennett · University of Colorado Anschutz Medical Campus

H.-Christian von Büdingen · Roche (Switzerland)

Briana Cameron

Robert Carruthers · University of British Columbia

Abstract

In this study, activated glial markers (in particular GFAP) and neurofilament heavy chain were associated specifically with nonrelapsing progressive disease outcomes (independent of acute inflammatory activity). Elevated CSF GFAP was associated with long-term MS disease progression.

Topics & Keywords

Multiple Sclerosis Research Studies Peripheral Neuropathies and Disorders Polyomavirus and related diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Neurology

Volume 81, Issue 4, pp. 373-373

DOI: 10.1001/jamaneurol.2024.0017

Field-Weighted Citation Impact: 33.04