Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling

202479 citationsJournal Articlehybrid Open Access

Authors

Shuang Chai · Luoyang Orthopedic-Traumatological Hospital of Henan Province

Yanbing Yang · Luoyang Orthopedic-Traumatological Hospital of Henan Province

Liwei Wei · Luoyang Orthopedic-Traumatological Hospital of Henan Province

Yuju Cao · Zhengzhou City Hospital

Jiangtao Ma · Luoyang Orthopedic-Traumatological Hospital of Henan Province

Xuxia Zheng · Luoyang Orthopedic-Traumatological Hospital of Henan Province

Abstract

In summary, Lut could improve mitochondrial dysfunction, alleviate GSDME-mediated pyroptosis and maintain osteogenesis via activating the PI3K/AKT axis, offering a new therapeutic strategy for PMOP.

Topics & Keywords

Inflammasome and immune disorders Bone Metabolism and Diseases Spondyloarthritis Studies and Treatments

Publication Details

Published in: Phytomedicine

Volume 128, pp. 155516-155516

DOI: 10.1016/j.phymed.2024.155516

Field-Weighted Citation Impact: 18.48

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Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling

Authors

Abstract

Topics & Keywords

Publication Details