Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies

2024163 citationsJournal Articlegreen Open Access

Authors

Christopher H. Gibbons · Beth Israel Deaconess Medical Center

Todd Levine · HonorHealth

Charles H. Adler · Mayo Clinic in Arizona

Bailey Bellaire · Synthetic Genomics (United States)

Ningshan Wang · Harvard University

Jade Stohl · Synthetic Genomics (United States)

Pinky Agarwal

Abstract

In this cross-sectional study, a high proportion of individuals meeting clinical consensus criteria for PD, DLB, MSA, and PAF had phosphorylated α-synuclein detected by skin biopsy. Further research is needed in unselected clinical populations to externally validate the findings and fully characterize the potential role of skin biopsy detection of phosphorylated α-synuclein in clinical care.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Botulinum Toxin and Related Neurological Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 331, Issue 15, pp. 1298-1298

DOI: 10.1001/jama.2024.0792

Field-Weighted Citation Impact: 58.70