Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19

202410 citationsJournal Articlegreen Open Access

Authors

Sascha N. Goonewardena · Michigan Medicine

Qinzhong Chen · Cardiovascular Institute of the South

Ashley M. Tate · Michigan Medicine

Olga Grushko · G. H. Gillespie Associates (United States)

Dilna Damodaran · Michigan Medicine

Pennelope Blakely · Michigan Medicine

Salim S. Hayek

Abstract

Taken together, these observations further elucidate the pathological mechanisms that underlie immune dysfunction and coagulation abnormalities in COVID-19, contributing to our growing understanding of SARS-CoV-2 infections that could also be leveraged to develop novel diagnostic and therapeutic strategies.

Topics & Keywords

COVID-19 Clinical Research Studies Long-Term Effects of COVID-19 Thermal Regulation in Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 44, Issue 5, pp. 1124-1134

DOI: 10.1161/atvbaha.122.318721

Field-Weighted Citation Impact: 3.89