MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway

202414 citationsJournal Articlegold Open Access

Authors

Karina Cañón-Beltrán · Universidad Complutense de Madrid

Yulia N. Cajas · Universidad Técnica Particular de Loja

Vasileios Almpanis · Institute for Research and Technology in Food and Agriculture

Sandra Guisado Egido · Institute for Research and Technology in Food and Agriculture

Alfonso Gutiérrez‐Adán · Institute for Research and Technology in Food and Agriculture

E. González · Universidad Complutense de Madrid

Abstract

Our findings suggest that supplementation of bta-miR-148b mimics during the entire culture period (D1 - D7) or from D1 - D4 improves embryo quality and influences the TGF-β signaling pathway by altering the transcription of genes associated with cellular differentiation and proliferation. This highlights the importance of miR-148b on embryo quality and development.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation Pregnancy and preeclampsia studies

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Biological Research

Volume 57, Issue 1, pp. 11-11

DOI: 10.1186/s40659-024-00488-z

Field-Weighted Citation Impact: 3.34