PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

20241 citationsJournal Articlehybrid Open Access

Authors

Elena Meuser · Cardiff University

Kyle Chang · The University of Texas MD Anderson Cancer Center

Angharad Walters · Cardiff University

Joanna J. Hurley · Cwm Taf University Health Board

Hannah D. West · Cardiff University

Iain Perry · Swansea University

Matthew Mort ·

Abstract

PIGA somatic mutation in duodenal tumors from patients with FAP and MAP and loss of membrane GPI-anchors may present new opportunities for understanding and intervention in duodenal tumorigenesis.

Topics & Keywords

Glycosylation and Glycoproteins Research Genetic factors in colorectal cancer Chronic Lymphocytic Leukemia Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer Research

Volume 22, Issue 6, pp. 515-523

DOI: 10.1158/1541-7786.mcr-23-0810

Field-Weighted Citation Impact: 0.23