Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice

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Authors

Steffen E. Künzel · Freie Universität Berlin

Inga-Marie Pompös · Charité - Universitätsmedizin Berlin

Leonie T. M. Flesch · Freie Universität Berlin

Dominik P. Frentzel · Charité - Universitätsmedizin Berlin

Vitus A. Knecht · Charité - Universitätsmedizin Berlin

Silvia Winkler · Charité - Universitätsmedizin Berlin

Sergej Skosyrski

Abstract

Saccharin appears to play a protective role in patients with nAMD undergoing intravitreal anti-VEGF treatment, aiding in better pathological lesion control and scar reduction. The murine study supports this observation, proposing saccharin's potential in mitigating pathological VEGFR-1-induced immune responses potentially via the RPE sensing saccharin in the blood stream.

Topics & Keywords

Biochemical Analysis and Sensing Techniques Olfactory and Sensory Function Studies melanin and skin pigmentation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 65, Issue 4, pp. 5-5

DOI: 10.1167/iovs.65.4.5

Field-Weighted Citation Impact: 1.29

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