Serotonin Syndrome and Dextromethorphan Toxicity Caused by Drug-Drug Interaction Between Fluoxetine and Bupropion-Dextromethorphan

20245 citationsJournal Articlebronze Open Access

Authors

Michelle Anjali Singh · University of California San Diego

Devon Johnson · University of California San Diego

Abstract

Addition of bupropion-dextromethorphan (BUP/DXM) to existing fluoxetine treatment resulted in serotonin syndrome within 3 days, with symptoms prompting presentation to the ED 5 days after discontinuation of BUP/DXM.

Topics & Keywords

Electroconvulsive Therapy Studies Pharmacological Receptor Mechanisms and Effects Fluorine in Organic Chemistry

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Psychiatry

Volume 85, Issue 2

DOI: 10.4088/jcp.23cr15139

Field-Weighted Citation Impact: 2.01