Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition

202433 citationsJournal Articlehybrid Open Access

Authors

Myrofora Panagi

Fotios Mpekris

Chrysovalantis Voutouri

Andreas G. Hadjigeorgiou

Chloe Symeonidou · Cyprus Research and Innovation Center (Cyprus)

Eleni Porfyriou · University of Cyprus

Christina Michael

Andreas Stylianou

John D. Martin · Materia (United States)

Horacio Cabral

Abstract

Our study suggests the targeting of MCs with clinically administered drugs, such as antihistamines, as a promising approach to overcome resistance to immunotherapy in sarcomas.

Topics & Keywords

Mast cells and histamine Polyamine Metabolism and Applications Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 30, Issue 11, pp. 2582-2597

DOI: 10.1158/1078-0432.ccr-24-0246

Field-Weighted Citation Impact: 8.01