Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11

202467 citationsJournal Articlegold Open Access

Authors

Zixi Wang · Anhui Medical University

Huaiyuan Zong · Anhui Medical University

Weiwei Liu · Anhui Medical University

Wei Lin · Anhui Medical University

Anjiang Sun · Anhui Medical University

Ding Zhao · Anhui Medical University

Xu Chen ·

Abstract

The ERO1α/IL-6/STAT3/SLC7A11 pathway is crucial for mTORC1-mediated ferroptosis resistance and tumor growth, and combining ERO1α inhibition with ferroptosis inducers is a novel and effective treatment for mTORC1-related tumors.

Topics & Keywords

Ferroptosis and cancer prognosis RNA modifications and cancer Cancer-related gene regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Experimental & Clinical Cancer Research

Volume 43, Issue 1, pp. 112-112

DOI: 10.1186/s13046-024-03039-2

Field-Weighted Citation Impact: 30.25