Perivascular Spaces, Diffusivity Along Perivascular Spaces, and Free Water in Cerebral Small Vessel Disease

202485 citationsJournal Articlegreen Open Access

Authors

Hao Li · Radboud University Nijmegen

Mina A. Jacob · Radboud University Nijmegen

Mengfei Cai · Radboud University Nijmegen

Roy P. C. Kessels · Radboud University Nijmegen

David G. Norris · Radboud University Nijmegen

Marco Duering · Radboud University Nijmegen

Frank‐Erik de Leeuw

Abstract

Our results showed that increased BG-PVS volumes, increased FW fraction, and decreased DTI-ALPS are related to progression of MRI markers of SVD, along with SVD-related cognitive decline over time. These findings may suggest that the glymphatic dysfunction is related to SVD progression, but further studies are needed.

Topics & Keywords

Cerebrospinal fluid and hydrocephalus Spinal Dysraphism and Malformations Fetal and Pediatric Neurological Disorders

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Neurology

Volume 102, Issue 9, pp. e209306-e209306

DOI: 10.1212/wnl.0000000000209306

Field-Weighted Citation Impact: 22.62