Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C

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Authors

Celia Gomar · Universidad de Navarra

Claudia Augusta Di Trani · Universidad de Navarra

Ángela Bella · Universidad de Navarra

Leire Arrizabalaga · Universidad de Navarra

José González-Gomariz · Universidad de Navarra

Myriam Fernández-Sendin · Universidad de Navarra

Maite Álvarez ·

Abstract

Intratumoral injection of poly(I:C) sensitizes MHC<sup>low</sup> tumors to the antitumor effects of artLCMV-E7E6, resulting in a potent therapeutic synergy.

Topics & Keywords

Viral Infections and Outbreaks Research Virus-based gene therapy research Immunotherapy and Immune Responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal for ImmunoTherapy of Cancer

Volume 12, Issue 4, pp. e008287-e008287

DOI: 10.1136/jitc-2023-008287

Field-Weighted Citation Impact: 2.34