Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

202413 citationsJournal Articlehybrid Open Access

Authors

Konstantin Kahnert · University of Copenhagen

Luca Soattin · University of Manchester

Robert W. Mills · University of Copenhagen

Claire Wilson · University of Liverpool

Svetlana Maurya · University of Copenhagen

Andrea Sorrentino · University of Copenhagen

Sami Al-Othman ·

Abstract

Collectively, we outline the protein and phosphorylation remodeling of SND in heart failure, we highlight a role for inflammation in electrophysiological remodelling of the sinus node, and we present galectin-3 signalling as a target to ameliorate SND in heart failure.

Topics & Keywords

Fuel Cells and Related Materials Advanced battery technologies research Membrane-based Ion Separation Techniques

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cardiovascular Research

Volume 120, Issue 8, pp. 927-942

DOI: 10.1093/cvr/cvae054

Field-Weighted Citation Impact: 2.71