Comparison of fidaxomicin, metronidazole and vancomycin for initial episode and recurrence of Clostridioides difficile infection - An observational cohort study

Fidaxomicin treated patients had statistically increased odds of rCDI. Compared to other treatments, fidaxomicin was inferior to metronidazole for rCDI in our cohort;Hypervirulent <i>C. difficile</i> was not associated with death.Vancomycin resistance of <i>C. difficile</i> statistically decreased, whereas metronidazole resistance did not vary during the studied period.