Reduced Congestion and Improved Response to a Fluid/Sodium Challenge in Chronic Heart Failure Patients After Initiation of Sacubitril/Valsartan: The NATRIUM-HF Study

The initiation of sacubitril/valsartan in HFrEF patients was associated with improvements in natriuresis, diuresis, and weight loss and better clinical adaptation to potentially decongestive stressors.