Eculizumab for paroxysmal nocturnal hemoglobinuria: Two cases of successful pregnancy outcomes

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Authors

Jovanka Ilic · Klinički centar Vojvodine

Borislava Pujić · Klinički centar Vojvodine

Branislava Jakovljević · Klinički centar Vojvodine

Borivoj Sekulić · University of Novi Sad

Danijela Agić · University of Novi Sad

Amir El Farra · University of Novi Sad

Branimir Micanovic ·

Abstract

Paroxysmal nocturnal hemoglobinuria is a rare disease with the incidence ranging from 0.08 to 0.57 per 100,000 person-years. Up to 25% of cases in women are detected during pregnancy. We report two cases of successful pregnancy outcomes in patients treated with eculizumab, pointing out the importance of interdisciplinary approach in these high-risk pregnancies.

Topics & Keywords

Complement system in diseases Renal Diseases and Glomerulopathies Coagulation, Bradykinin, Polyphosphates, and Angioedema

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Case Reports

Volume 12, Issue 5, pp. e8900-e8900

DOI: 10.1002/ccr3.8900

Field-Weighted Citation Impact: 0.25