Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice

202449 citationsJournal Articlehybrid Open Access

Authors

Paola Paone · UCLouvain

Dimitrios Latousakis · Norwich Research Park

Romano Terrasi · UCLouvain

Didier Vertommen · de Duve Institute

Ching Jian · University of Helsinki

Valentina Borlandelli · Leiden University

Francesco Suriano ·

Abstract

Our results show that the HMO 2'FL influences host metabolism by modulating the mucus layer, gut microbiota and eCB system and propose the mucus layer as a new potential target for the prevention of obesity and related disorders.

Topics & Keywords

Gut microbiota and health Infant Nutrition and Health Digestive system and related health

Publication Details

Published in: Gut

Volume 73, Issue 10, pp. 1632-1649

DOI: 10.1136/gutjnl-2023-330301

Field-Weighted Citation Impact: 11.46

Command Palette

Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice

Authors

Abstract

Topics & Keywords

Publication Details