Interstitial and Intraluminal Photodynamic Therapy – The Munich Experiences

Different clinical aspects of photodynamic therapy (PDT), like treatment planning, treatment and dosimetry protocols, spectral on-line-monitoring (SOM) as well as follow-up evaluation of clinical outcome, are of interest regarding further iPDT developments. For three specific applications, interstitial PDT (iPDT) for prostate cancer in urology, intraluminal PDT for cholangiocarcinoma in gastroenterology and stereotactic iPDT for glioblastoma in neurosurgery, the clinical scenario is described. If all information arising around a PDT intervention is combined, as shown on the example iPDT for glioblastoma, further insight about the involved processes and mechanisms can be derived and utilized to develop the therapeutic approach further as a whole.