<i>HLA-DQA1*05</i> Allele Carriage and Anti-TNF Therapy Persistence in Inflammatory Bowel Disease

20244 citationsJournal Articlebronze Open Access

Authors

Jayne Doherty · Tallaght University Hospital

Anthony W. Ryan · DS Biopharma (Ireland)

Emma M. Quinn · DS Biopharma (Ireland)

Judith Conroy · DS Biopharma (Ireland)

Jackie Dolan · DS Biopharma (Ireland)

R Corcoran · Trinity College

Fintan O Hara ·

Abstract

Carriage of 2 HLA-DQA1*05 alleles is associated with less favorable outcomes for patients receiving anti-TNF therapy with shorter time to therapy failure. HLA-DQA1*05 genotype status in conjunction with clinical factors may aid in therapy selection in patients with IBD.

Topics & Keywords

Inflammatory Bowel Disease Microscopic Colitis Eosinophilic Esophagitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Inflammatory Bowel Diseases

Volume 31, Issue 4, pp. 903-911

DOI: 10.1093/ibd/izae138

Field-Weighted Citation Impact: 1.66