Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy

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Authors

Leelabati Biswas · Rutgers, The State University of New Jersey

Katarzyna M. Tyc · Rutgers, The State University of New Jersey

Mansour Aboelenain · Rutgers, The State University of New Jersey

Siqi Sun · Rutgers, The State University of New Jersey

Iva Dundović · Ruđer Bošković Institute

Kruno Vukušić · Ruđer Bošković Institute

Jason Liu

Abstract

The study identifies novel genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and demonstrates that variants in kinesin genes, specifically <i>KIF18A</i> , contribute to increased aneuploidy and accelerated reproductive aging, offering potential for personalized fertility medicine.

Topics & Keywords

Assisted Reproductive Technology and Twin Pregnancy Reproductive Biology and Fertility Genetic and Kidney Cyst Diseases

Publication Details

Published in: medRxiv

DOI: 10.1101/2024.07.04.24309950

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Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy

Authors

Abstract

Topics & Keywords

Publication Details