P-64 MULTicentric HIV patients tracer for clinicAl assistanCe and rEsearch: feasibility, preliminary data from the MULTIFACE study

<h3>Background</h3> E-health-based clinical tracking is emerging as a crucial tool for remotely monitoring people with HIV (PWH) in order to optimize clinical resources, with particular regard to Patient Reported Outcomes (PROs), which are emerging as a key aspect in the monitoring of PWH. <h3>Objectives</h3> The aim of this study was to develop a model for remote PROs monitoring, assisting clinicians in disease tracking and patients management by establishing collaborative remote care. <h3>Materials and Methods</h3> A three-center intervention study on adult PWH undergoing antiretroviral therapy, diagnosed with HIV for more than 3 months, providing informed content and capable of using smart devices was designed. We developed and implemented a remote monitoring program leveraging on the Healthentia mobile App, able to submit and collect a set of questionnaires (HIVSRQ, ADH5Q, GAD-7, PHQ-9, HSS), tailored to individual needs identified from the screening questionnaire (EQ5D3L) thanks to an algorithm-based pathway. Any altered answers in the questionnaires generate alerts that are reported to the clinical team via a dashboard in real-time. Data privacy is ensured through a multisite setting, with each hospital acting as a site, thereby restricting patient and healthcare professional data to their centers. <h3>Results</h3> As of March 31, 2024, after 1 month from study starting, 136 PWH were enrolled, of whom 84 were men (61.8%), with an average age of 50.97 (SD: 11.1). Among them, 119 PWH filled-in at least 1 questionnaire (83.8% EQ5D, 18.4% HIVSQR, 16.2% ADH5d, 38.2% GAD-7, 38.2% PHQ-9, as reported in figure 1). The mean VAS score of screening EQ5D-3L questionnaire was 80.5 (IQR 71.0–91.0). Overall, 90 alerts were generated, of which stratification by cathegories is shown in figure 2. Furthermore, a preliminary analysis of the responses to the questionnaires was performed. In particular 50% of the alerts came from psychological distress (PHQ-9 and GAD-7) and 26% from symptoms (HIVSQR). The most frequently occurring domain of HIVSQR generating alerts was related to neuromuscular symptoms, as shown in figure 3. <h3>Conclusions</h3> The collection of PROs is a means to optimise management of PWH if there is an immediate return to the physician that allows intervention in clinical practice. The most relevant interaction between PWH and physicians is related to mental health issues followed by neuromuscolar symptoms. The results of this study, although preliminary, demonstrate feasibility of such an approach and suggest that patient need-based interviews with real-time return to the physicians may represent an advanced model of patient-centered interactive management thanks to IT applications. Relevance and scalability will be assessed. This study was made possible thanks to an unconditional grant from the ‘Fondazione Salute e Sanità’