Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction

202412 citationsJournal Articlegreen Open Access

Authors

Chen Gao · University of Cincinnati

Zhaojun Xiong · Sun Yat-sen University

Yunxia Liu · National Heart Centre Singapore

Meng Wang · Wuhan University

Menglong Wang · Wuhan University

Tian Liu · University of Cincinnati

J.P. Liu · Wuhan University

Abstract

These findings identify glucagon receptor signaling in cardiomyocytes as a critical determinant of HFpEF progression and provide proof-of-concept support for glucagon receptor antagonism as a potential therapy for the disease.

Topics & Keywords

Cardiovascular Function and Risk Factors Heart Failure Treatment and Management Diabetes Treatment and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 135, Issue 5, pp. 614-628

DOI: 10.1161/circresaha.124.324706

Field-Weighted Citation Impact: 4.83