Genome‐wide meta‐analysis identifies ancestry‐specific loci for Alzheimer's disease

202413 citationsReviewhybrid Open Access

Authors

Yi‐Jun Ge · State Key Laboratory of Medical Neurobiology

Shi‐Dong Chen · Fudan University

Bang‐Sheng Wu · Huashan Hospital

Ya‐Ru Zhang · State Key Laboratory of Medical Neurobiology

Jun Wang · Army Medical University

Xiao‐Yu He · Fudan University

Wei‐Shi Liu ·

Abstract

Loci KIAA2013, SLC52A3, and TCN2 were associated with Alzheimer's disease (AD) in Chinese populations. rs1815157 within the EGFR locus was associated with AD in Chinese populations. The genetic architecture of AD varied between Chinese and European populations. EGFR and TCN2 were prioritized as two of the most biologically significant genes. High mean corpuscular hemoglobin concentrations might have protective effects against AD.

Topics & Keywords

Genetic Associations and Epidemiology Bioinformatics and Genomic Networks Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 20, Issue 9, pp. 6243-6256

DOI: 10.1002/alz.14121

Field-Weighted Citation Impact: 7.10