Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats

Our findings reveal enrichment of AR45 and G_αq protein expression within the hippocampal-ETC circuit, which is vulnerable to oxidative stress and neurodegeneration during cognitive decline. Nonetheless, CIH does not modulate the expression of AR45 or G_αq. Importantly, there are sex differences in AR45 expression and its association with G_αq expression in various brain regions, which may underlie sex-specific differences in cognitive and motor function-associated declines with aging.