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<h3>Introduction/Purpose</h3> Endovascular electrode arrays provide a minimally invasive approach to access intracranial structures for neural recording and stimulation. These arrays are currently utilised as brain-computer interfaces (BCIs) and are deployed within the superior sagittal sinus, although cortical vein implantation could improve the quality and quantity of recorded signals. However, the anatomy of the superior cortical veins is heterogenous and poorly characterised. <h3>Materials and Methods</h3> MEDLINE and Embase databases were systematically searched from inception to 15th December 2023, for studies describing anatomy of superior cortical veins. Risk of bias assessment was performed using the Anatomical Quality Assurance (AQUA) tool from the International Evidence-Based Anatomy (iEBA) working group. <h3>Results</h3> A total of 27 studies were included: 19 cross-sectional imaging studies, 6 cadaveric studies, 1 intraoperative anatomical study and 1 review. There was substantial variability in cortical vein diameter, length, confluence angle, and location relative to underlying cortex (tables 1 and 4). The mean number of SSS branches ranged from 11–45 (table 2). The vein of Trolard was most often reported as the largest superior cortical vein, with a mean diameter ranging from 2.1 mm-3.3 mm (table 3). The mean vein of Trolard was identified posterior to the central sulcus. One study found a significant age-related variability in cortical vein diameter, and another identified myoendothelial sphincters at the base of cortical veins. <h3>Conclusion</h3> Cortical vein anatomical data is limited and inconsistent. The vein of Trolard is the largest tributary vein of the superior sagittal sinus, however its relation to underlying cortex is variable. Variability in cortical vein anatomy may necessitate individualised pre-procedural planning of training and neural decoding in endovascular BCI. Future focus on cortical vein relation to underlying cortex, sulcal vessels, and vessel wall anatomy is required. <h3>Disclosures</h3> <b>J. Brannigan:</b> 2; C; Synchron. <b>A. McClanahan:</b> 2; C; Synchron. <b>F. Hui:</b> None. <b>K. Fargen:</b> None. <b>N. Pinter:</b> None. <b>T. Oxley:</b> 4; C; Synchron. 5; C; Synchron.