Novel Biomarkers Reveal Mismatch Between Tissue and Serum Thyroid Hormone Status in Amiodarone-Induced Hyperthyroidism

20240 citationsJournal Articlehybrid Open Access

Authors

Richárd Sinkó · HUN-REN Institute of Experimental Medicine

Mónika Katkó · University of Debrecen

Géza Tóth · Hôpital Saint Lazare

Gábor L. Kovaćs · North Central College

Orsolya Dohán · Semmelweis University

Tibor Fülöp · University of Debrecen

Patrício Costa ·

Abstract

We developed a minimally invasive approach using HF markers to assess tissue TH economy that could complement routine diagnostics in controversial cases. We observed that a substantial proportion of patients with AIH do not develop tissue hyperthyroidism, indicating that amiodarone protects tissues from thyrotoxicosis. Assessing tissue TH action in patients with AIH may be warranted for treatment decisions.

Topics & Keywords

Thyroid Disorders and Treatments Ion channel regulation and function Growth Hormone and Insulin-like Growth Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 110, Issue 2, pp. 374-386

DOI: 10.1210/clinem/dgae514

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