Mitochondrial genome variants associated with amyotrophic lateral sclerosis and their haplogroup distribution

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Authors

Marcelo R. S. Briones · Universidade Federal de São Paulo

João H. C. Campos · Universidade Federal de São Paulo

Renata C. Ferreira · Universidade Federal de São Paulo

Lisa Schneper · Pennsylvania State University

Ilda M. Santos · Universidade Federal de São Paulo

Fernando Antoneli · Universidade Federal de São Paulo

James R. Broach

Abstract

Our study shows that mitogenome single nucleotide variants (SNVs) are associated with ALS and suggests that these SNVs could be included in routine genetic testing for ALS and that mitochondrial replacement therapy has the potential to serve as a basis for ALS treatment.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Neurological diseases and metabolism Mitochondrial Function and Pathology

Publication Details

Published in: Muscle & Nerve

Volume 70, Issue 4, pp. 862-872

DOI: 10.1002/mus.28230

Field-Weighted Citation Impact: 0.37

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Mitochondrial genome variants associated with amyotrophic lateral sclerosis and their haplogroup distribution

Authors

Abstract

Topics & Keywords

Publication Details