IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells

202415 citationsJournal Articlegold Open Access

Authors

Yi Zhang · City of Hope

Miso Park · City of Hope

Lucy Ghoda · City of Hope

Dandan Zhao · City of Hope

Melissa Valerio · City of Hope

Ebtesam Nafie · City of Hope

Asaul Gonzalez · City of Hope

Abstract

The novel anti-IL1RAP/CD3 TCE, BIF002, eradicates LSCs and significantly prolongs survival of AML xenografts, representing a promising, novel treatment for AML.

Topics & Keywords

CAR-T cell therapy research Immune Cell Function and Interaction Acute Myeloid Leukemia Research

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Journal of Hematology & Oncology

Volume 17, Issue 1, pp. 67-67

DOI: 10.1186/s13045-024-01586-x

Field-Weighted Citation Impact: 4.28