The Proteogenomics of Prostate Cancer Radioresistance

20243 citationsJournal Articlegold Open Access

Authors

Roni Haas · University of California, Los Angeles

Gavin Frame · Sunnybrook Health Science Centre

Shahbaz Khan · University Health Network

Beth K. Neilsen · University of California, Los Angeles

Boon Hao Hong · National Cancer Centre Singapore

Celestia P.X. Yeo · National Cancer Centre Singapore

Takafumi N. Yamaguchi

Abstract

Radiation is standard of care in prostate cancer. Yet, we have little understanding of its failure. We demonstrate a new paradigm that radioresistance is fractionation specific and identified POLQ as a radioresistance modulator.

Topics & Keywords

Prostate Cancer Treatment and Research Advanced Proteomics Techniques and Applications Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Research Communications

Volume 4, Issue 9, pp. 2463-2479

DOI: 10.1158/2767-9764.crc-24-0292

Field-Weighted Citation Impact: 1.26