Direct and Indirect Effect of Guselkumab on Anxiety, Depression, and Quality of Life in Patients with Moderate-to-Severe Plaque Psoriasis: A Mediation Analysis

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Authors

April W. Armstrong · University of California, Los Angeles

Peter Foley · The University of Melbourne

Yan Liu · Janssen (United States)

Mitchell D. Miller · Janssen (United States)

Rachel E. Teneralli · Janssen (United States)

Anthony Bewley · Barts Health NHS Trust

Kenneth B. Gordon

Abstract

GUS-mediated improvements in anxiety, depression, and overall HRQoL are not solely mediated by resolution of PsO signs, suggesting GUS use has a potential direct effect on anxiety and depression.

Topics & Keywords

Psoriasis: Treatment and Pathogenesis Dermatology and Skin Diseases Complementary and Alternative Medicine Studies

Publication Details

Published in: Dermatology and Therapy

Volume 14, Issue 9, pp. 2577-2589

DOI: 10.1007/s13555-024-01250-9

Field-Weighted Citation Impact: 1.68

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Direct and Indirect Effect of Guselkumab on Anxiety, Depression, and Quality of Life in Patients with Moderate-to-Severe Plaque Psoriasis: A Mediation Analysis

Authors

Abstract

Topics & Keywords

Publication Details