Pharmacological Inhibition of <i>N</i>-Acylethanolamine Acid Amidase (NAAA) Mitigates Intestinal Fibrosis Through Modulation of Macrophage Activity

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Authors

Maria Francesca Nanì · University of Naples Federico II

Ester Pagano · University of Naples Federico II

Paola De Cicco · University of Naples Federico II

Giuseppe Lucariello · University of Naples Federico II

Fabio Cattaneo · University of Naples Federico II

Francesca Paola Tropeano · University of Naples Federico II

Donatella Cicia

Abstract

Our findings provide new insights into the pathophysiological mechanism of intestinal fibrosis and identify NAAA as a promising target for the development of therapeutic treatments to alleviate CD-related fibrosis.

Topics & Keywords

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease Pancreatic function and diabetes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Crohn s and Colitis

Volume 19, Issue 2

DOI: 10.1093/ecco-jcc/jjae132

Field-Weighted Citation Impact: 2.67