Envelope domain III E 324 , E 351 , and E 380 mutations lever adaptive evolution of DENV-1 genotype I

20245 citationsJournal Articlegreen Open Access

Authors

Tao Jiang · Soochow University

Chenxiao Huang · Soochow University

Qianqian Ruan · Sun Yat-sen University

Xiaorong Huang · Guangdong Provincial Center for Disease Control and Prevention

Chumin Liang · Guangdong Provincial Center for Disease Control and Prevention

Zhiqiang Chen · Soochow University

Xi Yu

Abstract

We provide evidence that minor sequence variation among dengue virus (DENV) strains can result in increased adaptability and virulence, impacting both the biology of the virus and the antiviral immune response. The genetic mutations of DENV-1 gained during continuous transmission and evolution will offer new clues for the design of novel vaccines against flaviviruses.

Topics & Keywords

Mosquito-borne diseases and control Malaria Research and Control Insect symbiosis and bacterial influences

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Virology

Volume 98, Issue 10, pp. e0118324-e0118324

DOI: 10.1128/jvi.01183-24

Field-Weighted Citation Impact: 2.69

Command Palette

Envelope domain III E <sub>324</sub> , E <sub>351</sub> , and E <sub>380</sub> mutations lever adaptive evolution of DENV-1 genotype I

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details